Therataxis – Publications – Articles

Articles–Martin Brady

Brady ML, Grondin R, Zhang Z, Pomerleau F, Powell D, Huettl P, Wilson M, Stice J, Gerhardt GA, Abramov V, Raghavan R. In-vitro and in-vivo performance studies of a porous infusion catheter designed for intraparenchymal delivery of therapeutic agents of varying size. J Neurosci Methods. 2022 Aug 1;378:109643. doi: 10.1016/j.jneumeth.2022.109643. Epub 2022 Jun 9. PMID: 35691412.
Raghu Raghavan and Martin L. Brady. Direct Simplicial Dynamics: simulations in biomechanics. Engineering Reports, 2:12109, 2021. DOI: 10.1002/eng2.12109.
Martin L. Brady, Raghu Raghavan, and John H. Sampson. Determinants of intraparenchymal infusion distributions: modeling and analyses of human glioblastoma trials. Pharmaceutics, 12(9):895, 2020.
Raghu Raghavan and Martin L. Brady. Efficient numerical solutions of Neumann problems from their probabilistic representations. Eng. Reports, 2:12108, 2020.
M. L. Brady, R. Raghavan, J. Mata, M. Wilson, S. Wilson, R. M. Odland, and W. C. Broaddus. Large-volume infusions into the brain: a comparative study of catheter designs. Stereotact. Funct. Neurosurg., 96:135-141, 2018.
M. L. Brady, King Scott Coffield, Thomas J. Kuehl, R. Raghavan, V. O. Speights Jr., Belur Patel, Scott Wilson, Mike Wilson and Rick M. Odland. A pilot study in intraparenchymal therapy delivery in the prostate: a comparison of delivery with a porous needle vs standard needle. BMC Urology 18:66, 2018. DOI: 10.1186/s12894-018-0378-8.
Raghu Raghavan, Martin L. Brady, and John H. Sampson. Delivering therapy to target: improving the odds for successful drug development. Ther. Deliv. 7(7):457-481, 2016.
Martin L. Brady, Raghu Raghavan, Walter Block, Benjamin Grabow, Chris Ross, Ken Kubota, Andrew Alexander, and Marina E. Emborg. The Relation between Catheter Occlusion and Backflow during Intraparenchymal Cerebral Infusions. Stereotact. Funct. Neurosurg. 93(2):102-109, 2015.
Martin L. Brady, Raghu Raghavan, Deep Singh, P J Anand, Adam S. Fleisher, Jaime Mata, William C. Broaddus, and William L. Olbricht. In-vivo performance of a micro-fabricated catheter for intraparenchymal delivery. Journal of Neuroscience Methods. 229: 76-83, 2014.
K. Sillay, A. Hinchman, L. Kumbier, D. Schomberg, C. Ross, K. Kubota, M. Brady, E. Brodsky, G. Miranpuri, and R. Raghavan. Strategies for the Delivery of Multiple Collinear Infusion Clouds in Convection-Enhanced Delivery in the Treatment of Parkinson's Disease. Stereotact. Funct. Neurosurg. 91:153-161, 2013.
Martin L. Brady, Raghu Raghavan, Andrew Alexander, Ken Kubota, Karl Sillay, and Marina E. Emborg. Pathways of Infusate Loss during Convection-Enhanced Delivery into the Putamen Nucleus. Stereotact. Funct. Neurosurg. 91:69-78, 2013.
Ankit I. Mehta, Bryan D. Choi, Divya Ajay, Raghu Raghavan, Martin Brady, Allan H. Friedman, Ira Pastan, Darell D. Bigner, and John H. Sampson. Convection Enhanced Delivery of Macromolecules for Brain Tumors. Current Drug Discovery Technologies, 9:305-310, 2012.
Martin Brady, Raghu Raghavan, Zhi-jian Chen, and William C. Broaddus. Quantifying fluid infusions and tissue expansion in brain. IEEE Transactions on Biomedical Engineering, 58:2228-2237, 2011.
Raghu Raghavan and Martin Brady. Predictive models of pressure-driven infusions into brain parenchyma. Physics in Medicine and Biology, 56:1-26, 2011.
Ankit I. Mehta, Bryan D. Choi, Raghu Raghavan, Martin Brady, Allan H. Friedman, Darell D. Bigner, Ira Pastan, and John H. Sampson. Imaging of Convection Enhanced Delivery of Toxins in Humans. Toxins, 3:201-206, 2011.
John H Sampson, Martin Brady, Raghu Raghavan, Ankit I Mehta, Allan H Friedman, David A Reardon, Neil A Petry, Daniel P Barboriak, Terence Z Wong, Michael R Zalutsky, Denise M Lally-Goss, and Darell D Bigner. Co-localization of gadolinium-DTPA with high molecular weight molecules after intracerebral convection-enhanced delivery in man. Neurosurgery, 98:1-7, 2011.
M. E. Emborg, V. Joers, R. Fisher, K. Brunner, V. Carter, C. Ross, R. Raghavan, M. Brady, J. Raschke, K. Kubota, and A. Alexander. Intraoperative intracerebral MRI-guided navigation for accurate targeting in non-human primates. Cell Transplantation, 19:1587-1597, 2010.
Raghu Raghavan, Samuel Mikaelian, Martin Brady, and Zhi-Jian Chen. Fluid infusions from catheters into elastic tissue I: azimuthally symmetric backﬂow in homoge¬neous media. Physics in Medicine and Biology, 55:281-304, 2010.
J. H. Sampson, G. E. Archer, C. Pedain, E. Wembacher-Schroder, M. Westphal, S. Kunwar, M. A. Vogelbaum, A. Coan, J. E. Herndon, R. Raghavan, M. L. Brady, D. A. Reardon, A. H. Friedman, H. S. Friedman, I. Rodríguez-Ponce, S. Chang S. Mittermeyer, D. Croteau, and R. Puri. Poor drug distribution as a possible explanation for the results of the PRECISE trial. Journal of Neurosurgery, 113:301-309, 2010.
Sampson, J.H., Brady, M.L., Petry, N.A., Croteau, D., Friedman, A.H., Friedman, H.S., Wong, T., Bigner, D.D., Pastan, I., Puri, R.K., Pedain, C.: Intracerebral infusate distribution by convection-enhanced delivery in humans with malignant gliomas: descriptive effects of target anatomy and catheter positioning. Neurosurgery 60(2) Supplement 1:89-99, Feb. 2007.
Sampson, J.H., Raghavan, R., Brady, M., Provenzale, J., Herndon, II, J., Croteau, D., Friedman, A., Reardon, D., Coleman, R.E., Wong, T., Bigner, D., Pastan, I., Rodriguez-Ponce, M., Tanner, P., Puri, R., Pedain, C.: Clinical Utility of a Patient-specific Algorithm for Simulating Intracerebral Drug Infusions. Neuro-oncol., Apr. 13, 2007.
R. Raghavan, Brady, M.L., Rodriguez-Ponce, M.I., Hartlep, A., Pedain, C., Sampson, J.H., Convection-enhanced delivery of therapeutics for brain disease, and its optimization. Neurosurg. Focus (20), Apr. 2006.
John H. Sampson, Allan H. Friedman, David A. Reardon, Henry S. Friedman, James M. Provenzale, Darell D. Bigner, Martin Brady, Raghu Raghavan, Christoph Pedain, Gary E. Archer, Denise Lally-Batts, Amy Grahn, Theodora Cohen, Jeanne L. Dul, David Croteau, Raj K. Puri, Convection-enhanced delivery of IL13-PE38QQR in malignant glioma: Effect of catheter placement on drug distribution, Abstract, Proceedings of the American Association of Neurological Surgeons Annual Meeting, May 2004.
M.A. Bauman, G.T. Gillies, R. Raghavan, M.L. Brady, C. Pedain. Physical characterization of neurocatheter performance in a brain phantom gelatin with nanoscale porosity: steady-state and oscillatory flows. Nanotechnology 15, pp. 92-97, 2004.
Zvi Ram, Yael Mardor, Tali Jonas, Martin Brady, Raghu Raghavan, Christoph Pedain, and Philipp Tanner. Preliminary assessment of a model for predicting convection-enhanced delivery. Proceedings of the American Association of Neurological Surgeons Annual Meeting, Apr. 2003.
Zvi Ram, Zvi Lidar, Raphael Pfeer, Yiftach Roth, Tali Jonas, Dvora Nass, Martin Brady, Raghu Raghavan, Christoph Pedain, Philipp Tanner, and Yael Mardor. Convection-enhanced taxol delivery for treatment of recurrent glioblastoma; radiological/clinical experience and applications for treatment optimization. Abstract, Proceedings of the Annual Meeting of the Israel Society of Oncology and Radiotherapy, 2003.
F. Weber, E. Bauer, M. Brady, R. Raghavan, A. Hartlep, and C. Pedain. Assessing drug disposition in convection-enhanced delivery using Gd-DTPA and computerized modeling. Proceedings of the Society of Neurooncology, 2003
N. B. Conyer, R. Viswanathan, R. Raghavan, G. Mills, M. Brady, and M. J. Bronskill. Improved RF coils for internal imaging. Proceedings of the First IEEE International Symposium on Biomedical Imaging, page WP-125, 2002.
N. B. Conyer, R. Viswanathan, R. Raghavan, G. Mills, M. Brady, and M. J. Bronskill. Improved interstitial and intravascular RF coils. Proceedings of the Tenth ISMRM Meeting, page 2262, 2002.
N. Conyer, N. J. Lobaugh, G. Sela, R. Raghavan, G. Mills, M. Brady, R. Viswanathan, W. K. Sootsman, and M. J. Bronskill. Interstitial RF coil incorporating multiple microcatheters. Proceedings of the ISMRM-ESMRMB Joint Annual Meeting, page 2170, 2001.
M. L. Brady, W. E. Higgins and K. Ramaswamy, “Template-Based Approach for Virtual-Endoscopic Navigation”, SPIE Medical Imaging 1999: Physiology and Function from Multidimensional Images, A. Clough and C.T. Chen (eds), SPIE Proceedings, 1999, v. 3660, pp. 241-256
M. Brady, et al., “Interactive Haptic Modeling of Tensegrities and Network Structures”, SIGGRAPH '99 Sketches and Applications, pp. 252
M. Brady, "A Fast Discrete Approximation Algorithm for the Radon Transform", SIAM J. Computing, Feb. 1998, 27 (1), pp. 107-119
M. Brady, K. Jung, H. T. Nguyen and T. Nguyen, "Interactive Volume Navigation", IEEE Trans. Visualization & Comp. Graphics, Jul.-Sept. 1998, 4 (3), pp. 243-256
M. Brady, D. Brown and K. Powers, "Hexagonal Models for VLSI Routing", Algorithmica, 1997, 19, pp. 263-290
M. Brady, K. Jung, H. T. Nguyen and T. Nguyen, "Two-phase Perspective Ray Casting for Volume Navigation", Visualization '97, Oct. 1997, pp. 183-189
M. Brady, W. Higgins, K. Ramaswamy and R. Srinivasan. "Interactive Navigation Inside 3D Radiological Images", Workshop on Frontiers in Biomedical Visualization, 1995
B. Berger, M. Brady, D. J. Brown and F. T. Leighton, "Nearly Optimal Algorithms and Bounds for Multilayer Channel Routing", J. ACM, 1995, 42 (2), pp. 500-542
T. K. Wu and M. Brady, "Efficient Parallel Computation of Projections for Animated Volume Visualization”, Proc. Intl. Conf. on Parallel Processing, v. III, 1994
W. Yong and M. Brady, “Efficient Component Labeling on SIMD Mesh Processors”, Proc. Intl. Conf. on Parallel Processing, v. III, 1994
M. Brady, R. Raghavan, and J. Slawny. Back Propagation Fails to Separate where Perceptrons Succeed. IEEE Transactions on Circuits and Systems, 36:665—674, 1989.